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master's thesis
Pharmacokinetic Modeling of a Liver-Specific Contrast Agent
2018. urn:nbn:hr:160:422304
Alerić, Ivana
Josip Juraj Strossmayer University of Osijek
Department of Physics

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Alerić, I. (2018). Pharmacokinetic Modeling of a Liver-Specific Contrast Agent (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Physics. Retrieved from https://urn.nsk.hr/urn:nbn:hr:160:422304

Alerić, Ivana. "Pharmacokinetic Modeling of a Liver-Specific Contrast Agent." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Physics, 2018. https://urn.nsk.hr/urn:nbn:hr:160:422304

Alerić, Ivana. "Pharmacokinetic Modeling of a Liver-Specific Contrast Agent." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Physics, 2018. https://urn.nsk.hr/urn:nbn:hr:160:422304

Alerić, I. (2018). 'Pharmacokinetic Modeling of a Liver-Specific Contrast Agent', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Physics, accessed 12 November 2024, https://urn.nsk.hr/urn:nbn:hr:160:422304

Alerić I. Pharmacokinetic Modeling of a Liver-Specific Contrast Agent [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Physics; 2018 [cited 2024 November 12] Available at: https://urn.nsk.hr/urn:nbn:hr:160:422304

I. Alerić, "Pharmacokinetic Modeling of a Liver-Specific Contrast Agent", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Physics, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:160:422304

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Metadata
TitlePharmacokinetic Modeling of a Liver-Specific Contrast Agent
Title (croatian)Farmakokinetičko modeliranje specifičnog kontrasta za jetru
AuthorIvana Alerić
MentorMladen Kasabašić (mentor)
Committee memberDario Faj (predsjednik povjerenstva)
Committee memberMladen Kasabašić (član povjerenstva)
Committee memberSlavko Petrinšak (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Physics
Osijek
Defense date and country2018-10-19, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Biophysics and Medical Physics
Abstract
Measurement of liver function after embolization is based on the application of specific liver contrast agent which can be excreted through liver into the bile and recording the whole process with magnetic resonance. By closing the branch of the portal vein which enables food supply, we stimulate the growth of the second, healthy, part of the liver. The analysis of MRI recordings consists of several phases and gives curves that represent time-varying contrast concentrations in blood and liver tissue. By using pharmacokinetic models for fitting the curves we obtain parameters that describe the function of the liver; perfusion, contrast uptake and extraction rate, volume of hepatocytes and sinusoidal cells.
Abstract (croatian)
Mjerenje funkcije jetre nakon embolizacije temelji se na primjeni specifičnog kontrasta za jetru, koji se putem jetre izlucuje u žuć te snimanjem cijelog procesa magnetskom rezonancom. Zatvaranjem jednog kraka portalne vene koja omogućuje dovod hranjivih sastojaka, potiče se rast drugog dijela jetre koji na sebe preuz- ima funkciju djela zaraženog tumorom. Analiza snimaka magnetske rezonance, koja se sastoji od nekoliko faza, daje krivulje koje predstavljaju vremensku promjenu koncentracije kontrasta u krvi i tkivu jetre. Primjenom farmakokinetičkih modela za opisivanje krivulja dobivamo parametre koji opisuju funkciju jetre; perfuziju, brzinu apsorpcije te izlučivanja kontrasta, volumen hepatocita te sinusoidalnih stanica.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:160:422304
Study programmeTitle: Physics and Computer Science; specializations in: Teaching
Course: Teaching
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra edukacije fizike i informatike (magistar/magistra edukacije fizike i informatike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-10-23 06:41:49